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UF Health University of Florida
Department of Medicinal Chemistry College of Pharmacy
People Overview

Sebastiano Intagliata

Sebastiano Intagliata, Ph.D.
Sebastiano Intagliata, Ph.D.

Education

  • Postdoctoral Associate, University of Mississippi, Oxford, MS, USA
  • Ph.D. Pharmaceutical Sciences, University of Catania, Catania, Italy
  • M.S. Chemistry and Pharmaceutical Technology, University of Catania, Catania, Italy

Biographical Sketch

Dr. Sebastiano Intagliata received his M.S. in Chemistry and Pharmaceutical Technology and his Ph.D. in Pharmaceutical Sciences from the University of Catania under the supervision of Dr. Maria N. Modica. His doctoral project was focused on synthesis of new alkylpiperazines as 5-HT7 receptor ligands. During his Ph.D., Dr. Intagliata had the opportunity to spend five months as a visiting scholar in the laboratory of Prof. Andrzej J. Bojarski at the Institute of Pharmacology,Polish Academy of Sciences in Krakow, Poland, where he performed molecular modeling studies for 5-HT7 and 5-HT1A receptor homology models. In 2015, he spent a few months in the Department of Biomolecular Sciences at the University of Mississippi, where he worked, under the supervision of Dr. Christopher R. McCurdy, on the lead optimization of CM304, a highly selective sigma-1 receptor antagonist with analgesic activity in rodents. After the completion of his Ph.D., Dr. Intagliata returned to the University of Mississippi as a postdoctoral associate. In January 2017, he moved to the University of Florida College of Pharmacy’s Department of Medicinal Chemistry where he continued to work as a postdoctoral associate with Dr. McCurdy. Currently, his research is focused on developing novel sigma-1 and sigma-2 receptor ligands as potential treatments for pain and drug abuse as well as the development of new opioid derivatives.

Curriculum Vitae

Research Interests

  • Medicinal chemistry
  • Drug discovery and development
  • Pain
  • Drug abuse and addiction
  • CNS agents

Professional Affiliations

  • American Association of Pharmaceutical Sciences (AAPS)
  • National Postdoctoral Association (NPS)
  • Italian Chemical Society (SCI)

Select Publications

  1. Intagliata, S.; Modica, M.N.; Pittalà, V.; Salerno, L.; Siracusa, M.A.; Cagnotto, A.; Salmona, M.; Kurczab, R.; Romeo, G. New N– and O-arylpiperazinylalkyl pyrimidines and 2-methylquinazolines derivatives as 5-HT7 and 5-HT1A receptor ligands: Synthesis, structure-activity relationships, and molecular modeling studies. Bioorg. Med. Chem., 2017, 25, 1250.
  2. Intagliata, S.; Modica, M.N.; Pittalà, V.; Salerno, L.; Siracusa, M.A.; Cagnotto, A.; Salmona, M.; Romeo, G. Design and synthesis of new homo and hetero bis-piperazinyl-1-propanone derivatives as 5-HT7R selective ligands over 5-HT1AR. Bioorg. Med. Chem. Lett., 2016, 26, 4052.
  3. Modica, M.N.; Intagliata, S.; Pittalà, V.; Salerno, L.; Siracusa, M.A.; Cagnotto, A.; Salmona, M.; Romeo, G. Synthesis and binding properties of new long-chain 4-substituted piperazine derivatives as 5-HT1A and 5-HT7 receptor ligands. Bioorg. Med. Chem. Lett., 2015, 25, 1427.
  4. Salerno, L.; Pittalà, V.; Modica, M.N.; Siracusa, M.A.; Intagliata, S.; Cagnotto, A.; Salmona, M.; Kurczab, R.; Bojarski, A.J.; Romeo, G. Structure-activity relationships and molecular modeling studies of novel arylpiperazinylalkyl 2-benzoxazolones and 2-benzothiazolones as 5-HT7 and 5-HT1A receptor ligands. Eur. J. Med. Chem., 2014, 85, 716.

Contact Information

Email: s.intagliata@cop.ufl.edu