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UF Health University of Florida
Department of Medicinal Chemistry College of Pharmacy
People Overview

Yasmeen Abouelhassan

Yasmeen Abouelhassan
Yasmeen Abouelhassan

Education

  • Bachelor of Pharmacy, College of Pharmacy, Cairo University, Cairo, Egypt

Entry date into medicinal chemistry Ph.D. program: Fall 2013

Curriculum Vitae

Research Interests

  • Drug design
  • Organic chemistry
  • Microbiology

Professional Experience

  • Research Assistant, Medicinal Chemistry Department, College of Pharmacy, University of Florida; Advisor: Professor Robert W. Huigens III, 2014 – present
  • Teaching Assistant, Medicinal Chemistry Department, College of Pharmacy, University of Florida; Advisor: Professor Robert W. Huigens III, 2013 – 2014

Publications

  1. Yousaf, H. H.; Garrison, A. T.; Abouelhassan, Y.; Basak, A.; Jones, J. B.; Huigens III, R. W. “Identification of Nitroxoline and Halogenated Quinoline Analogues with Antibacterial Activities against Plant Pathogens.” ChemistrySelect, 2017, 2, 6235-6239.
  2. Basak, A.; Abouelhassan, Y.; Zuo, R.; Yousaf, H.; Ding, Y.; Huigens III, R. W. “Antimicrobial Peptide-Inspired NH125 Analogues: Bacterial and Fungal Biofilm-Eradicating Agents and Rapid Killers of MRSA Persisters.” Org. Biomol. Chem., 2017, 15, 5503-5512.
  3. Yang, H.; Abouelhassan, Y.; Burch, G. M.; Kallifidas, D.; Huang, G.; Yousaf, H.; Jin, S.; Luesch, H.; Huigens III, R. W. “A Highly Potent Class of Halogenated Phenazine Antibacterial and Biofilm-Eradicating Agents Accessed Through a Modular Wohl-Aue Synthesis.” Sci. Rep., 2017, 7, 2003.
  4. Abouelhassan, Y.; Basak, A.; Hussain, Y.; Huigens III, R. W. “Identification of N-Arylated NH125 Analogues as Rapid Eradicating Agents against MRSA Persister Cells and Potent Biofilm Killers of Gram-Positive Pathogens.” ChemBioChem, 2017, 18, 352-357.
  5. Abouelhassan, Y.; Yang, Q.; Nguyen, M. T.; Rolfe, M.; Yousaf, H. Schultz, G. S.; Huigens III, R. W. “Nitroxoline: A Broad-Spectrum Persister Cell- and Biofilm-Eradicating Agent Against Pathogenic Bacteria.” Int. J. Antimicrob. Agents, 2017, 49, 247-251.
  6. Garrison, A. T.; Abouelhassan, Y.; Yang, H.; Yousaf, H. H.; Nguyen, T.; Huigens III, R. W. “Microwave-Enhanced Friedländer Synthesis for the Rapid Assembly of Halogenated Quinolines with Antibacterial and Biofilm Eradication Activities against Drug Resistant and Tolerant Bacteria.” Med. Chem. Commun., 2017, 8, 720-724.
  7. Basak, A.; Abouelhassan, Y.; Norwood IV, V. M.; Bai, F.; Nguyen, M.; Jin, S.; Huigens III, R. W. “Synthetically Tuning the 2-Position of Halogenated Quinolines: Optimizing Antibacterial and Biofilm Eradication Activities via Alkylation and Reductive Amination Pathways.” Chem. Eur. J. 2016, 22, 9181-9189.
  8. Garrison, A. T.; Abouelhassan, Y.; Norwood IV, V. M.; Kallifidas, D.; Bai, F.; Nguyen, M.; Rolfe, M. Burch, G. M., Jin, S., Luesch, H.; Huigens III, R. W. “Structure-Activity Relationships of a Diverse Class of Halogenated Phenazines that Targets Persistent, Antibiotic-Tolerant Bacterial Biofilms and Mycobacterium tuberculosis.” J. Med. Chem. 2016, 59, 3808-3825.
  9. Garrison, A. T.; Abouelhassan, Y.; Kallifidas, D.; Bai, F.; Ukhanova, M.; Mai, V.; Jin, S.; Luesch, H.; Huigens III, R. W. “Halogenated Phenazines that Potently Eradicate Biofilms, MRSA Persister Cells in Non-Biofilm Cultures and Mycobacterium tuberculosis.” Angew. Chemie Int. Ed., 2015, 54, 14819-14823.
  10. Basak, A.; Abouelhassan, Y.; Huigens III, R. W. “Halogenated Quinolines Discovered Through Reductive Amination with Potent Eradication Activities against MRSA, MRSE and VRE Biofilms.” Org. Biomol. Chem., 2015, 13, 10290-10294.
  11. Abouelhassan, Y.; Garrison, A. T.; Bai, F.; Norwood IV, V. M.; Nguyen, M.; Jin, S.; Huigens III, R. W. “A Phytochemical-Halogenated Quinoline Combination Therapy Strategy for the Treatment of Pathogenic Bacteria” ChemMedChem, 2015, 10, 1157-1162.
  12. Garrison, A. T.; Bai, F.; Abouelhassan, Y.; Paciaroni, N. G.; Jin, S.; Huigens III, R.W. “Bromophenazine Derivatives with Potent Inhibition, Dispersion and Eradication Activities against Staphylococcus aureus Biofilms.” RSC Adv. 2015, 5, 1120-1124.
  13. Abouelhassan, Y.; Garrison, A. T.; Burch, G. M.; Wong, W.; Norwood IV, V. M.; Huigens III, R. W. “Discovery of quinoline small molecules with potent dispersal activities against methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis biofilms using a scaffold hopping strategy.” Bioorg. Med. Chem. Lett., 2014, 24, 5076-5080.

Contact Information

Email: y.abouelhassan@ufl.edu