- Ph.D., Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, GA, 2016
- B.S., Chemistry, Sweet Briar College, Sweet Briar, VA, 2010
Laura Hanold first began performing medicinal chemistry research during her undergraduate studies at Sweet Briar College, during which she focused on the synthesis and photochemistry of 3(2H)-furanones. Following the completion of her Bachelor of Science degree in 2010, she went on to pursue a Ph.D. in pharmaceutical and biomedical sciences at the University of Georgia, earning her doctorate in 2016. Her dissertation research focused on the synthesis and evaluation of peptides mimicking structural features of the epidermal growth factor receptor (EGFR) so as to disrupt protein-protein interactions that contribute to EGFR activation in cancer. In addition to her dissertation research, she synthesized a variety of constrained peptides as potential anti-cancer therapeutics in numerous collaborative projects. Dr. Hanold is currently a post-doctoral associate in the laboratory of Dr. Jane V. Aldrich, where she now focuses on the development of macrocyclic tetrapeptides as kappa opioid receptor antagonists and potential anti-cancer therapeutics.
- Peptide chemistry
- Drug discovery and development
- American Chemical Society (ACS)
- American Association for the Advancement of Science (AAAS)
- American Peptide Society (APS)
- A. Mukhopadhyay, L.E. Hanold, H. Thayele Purayil, S. Gisemba, S. Sanadheera, J.V. Aldrich. Macrocyclic peptides decrease c-Myc protein levels and reduce prostate cancer cell growth. Cancer Biol Ther. 2017. 18(8): 571-583.
- L.E. Hanold, M.D. Fulton, E.J. Kennedy. Targeting kinase signaling pathways with constrained peptide scaffolds. Pharmacol. Ther. 2017. 173: 159-170.
- L.E. Hanold, C.P. Watkins, N.T. Ton, P. Liaw, A.M. Beedle, E.J. Kennedy. Design of a Selenylsulfide-Bridged EGFR Dimerization Arm Mimic. Bioorg. Med. Chem., 2015. 23(12), 2761-2766.
- L.E. Hanold, K. Oruganty, N.T. Ton, A.M. Beedle, N. Kannan, E.J. Kennedy. Inhibiting EGFR Dimerization Using Triazolyl-Bridged Dimerization Arm Mimics. PLoS ONE, 2015, 10(3), e0118796.
For a full list of publications see my bibliography in PubMed.