Marco Mottinelli


Marco Mottinelli, Ph.D.
Marco Mottinelli, Ph.D.
  • Postdoctoral Research Associate, University of Mississippi, 2015-2016
  • Ph. D. Medicinal Chemistry, University of Bath, 2009-2014
  • M.S. Chemistry and Pharmaceutical Technology, University of Pisa, 2000-2008

Biographical Sketch

Marco Mottinelli received his Master’s degree in Chemistry and Pharmaceutical Technology at the University of Pisa, Italy. After graduating, he spent one year at DSM pharmaceutical products, the Netherlands, before moving to the University of Bath, England to pursue his Doctorate degree in medicinal chemistry. Upon completion of his Ph.D. on the synthesis and biological evaluation of novel chemical entities targeting estrogen biosynthesis and signaling for the treatment of breast cancer, Mottinelli moved to the University of Mississippi as a postdoctoral associate within the group of Dr. Christopher McCurdy. In 2017, Dr. Mottinelli joined the University of Florida as a postdoctoral research associate in the department of Medicinal Chemistry. His research focuses on the development of neurotherapeutics in the areas of pain and drug of abuse and more specifically on Neuropeptide FF receptor ligands.

Curriculum Vitae

Research Interests

  • Medicinal chemistry, lead-based and structure-based drug discovery and organic synthesis
  • In vitro biological evaluation

Professional Affiliations

  • American Chemical Society (ACS)
  • American Association of Pharmaceutical Scientists (AAPS)
  • Royal Society of Chemistry (RSC)

Select Publications

Mottinelli, M.; Leese, M. P.; Potter, B. V. L.; Accessing simply substituted 4-hydroxytetrahydroisoquinolines via pomeranz-fritsch-bobbitt reaction with non-activated and moderately-activated systems. Beilstein Journal of Organic Chememistry 2017 (13), 1871-1878.

Granchi, C.; Roy, S.; Mottinelli, M.; Nardini, E.; Cmpinoti, F.; Tuccinardi, T.; Lanza, M.; Betti, L.; Giannaccini, G.; Lucacchini, A.; Martinelli, A.; Macchia, M.; Minutolo, F. Synthesis of sulfonamide-containing N-hydroxyindole-2-carboxylates as inhibitors of human lactate dehydrogenase-isoform 5. Bioorganic and Medicinal Chemistry Letters 2011 (21), 7331–7336.

Busscher, G. F.; Lefort, L.; Cremers, J. G. O.; Mottinelli, M.; Wiertz, R. W.; De Lange, B.; Okamura, Y.; Yusa, Y.; Matsumura, K.; Shimizu, H.; De Vries, J. G.; De Vries, A. H. M.; Efficient preparation of an N-aryl β-amino acid via asymmetric hydrogenation and direct asymmetric reductive amination en route to Ezetimibe. Tetrahedron: asymmetry 2010 (21), 1709-1714.

Contact Information