Nicholas Paciaroni

Nicholas Paciaroni


  • B.S. Chemistry, Clemson University

Entry Date into the Medicinal Chemistry PhD program: 2013

Curriculum Vitae

Research Interest

  • Synthetic organic chemistry
  • Medicinal chemistry
  • Hit-to-lead synthesis design
  • Drug discovery screening

Professional Experience

  • Graduate Research Assistant, University of Florida Department of Medicinal Chemistry, Gainesville, FL (2013-present)
  • Undergraduate Research Assistant, Clemson University Department of Chemistry, Clemson, SC (2011-2013)
  • Quality Control Laboratory Technician, Ortec Inc., Piedmont, SC (2011)


  • CNPD3 Drug Discovery Symposium Graduate Student Oral Presentation Award (2017)
  • Charlotte M. Liberty Fellowship (2014-2016)


Paciaroni, N. G.; Ratnayake, R.; Matthews, J. H.; Norwood IV, V. M.; Arnold, A. C.; Dang, L. H.; Luesch, H.; Huigens III, R. W. “A Tryptoline Ring Distortion Strategy Leads to Complex and Diverse Biologically Active Molecules from the Indole Alkaloid Yohimbine.” Chem. Eur. J. 2017, 23, 4327.

Paciaroni, N. G.; Borrero, N. V.; Rocca, J. R.; Huigens III, R. W. “Rapid Synthesis of Phenazine-1-Carboxylic Acid Derived Small Molecules from Diverse Anilines: Privileged Structures for Discovery.” J. Org. Med. Chem. 2015, 1, 67.

Garrison, A. T.; Bai, F.; Abouelhassan, Y.; Paciaroni, N. G.; Jin, S.; Huigens III, R. W. “Bromophenazine Derivatives with Potent Inhibition, Dispersion and Eradication Activities against Staphylococcus aureus Biofilms.” RSC Adv. 2015, 5, 1120.

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