Sushobhan Mukhopadhyay, Ph.D.
Assistant Scientist
Department:
Medicinal Chemistry
Business Phone:
(352) 284-9649
Business Email:
smukhopadhyay@ufl.edu
About Sushobhan Mukhopadhyay
Sushobhan Mukhopadhyay, Ph.D., was appointed as an assistant scientist in the College of Pharmacy, Department of Medicinal Chemistry in July 2022. Sushobhan received his Bachelor of Science (Chemistry) and Master of Science (Organic Chemistry) degrees from University of Kalyani, India. He pursued his Ph.D. in Medicinal Chemistry from CSIR-Central Drug Research Institute, India in 2020. His doctoral work focused on the synthesis of new heterocycles, development of innovative synthetic methodologies, synthesis and biological evaluation of small molecules for anti-proliferative and anti-infective agent. Upon completion of his doctoral studies, Sushobhan joined the University of Florida, College of Pharmacy in December 2020 as a Postdoctoral Associate in the Department of Medicinal Chemistry working in Dr. Christopher McCurdy’s laboratory. Sushobhan has keen interest in the development of novel molecules for the treatment of pain and opioid use disorder.
Accomplishments
Early Career Achievement Award in Chemical Science
2020
·
CSIR-Central Drug Research Institute, India
Senior Research Fellow Award
2016
·
Council of Scientific & Industrial Research, India
Best Publication award in Chemical Science
2015
·
CSIR-Central Drug Research Institute, India
Junior Research Fellowship
2014
·
Council of Scientific and Industrial Research, India
Research Profile
Areas of Interest
- Substance Use Epidemiology, particularly opioids
- Drug development
- Medicinal chemistry
- Natural products
- Organic Chemistry
Publications
2024
Effects of kratom on driving: Results from a cross-sectional survey, ecological momentary assessment, and pilot simulated driving Study.
Traffic injury prevention.
25(4):594-603
[DOI] 10.1080/15389588.2024.2327827.
[PMID] 38497810.
2024
Formation of multiple ion types during MALDI imaging mass spectrometry analysis of Mitragyna speciosa alkaloids in dosed rat brain tissue.
Talanta.
274
[DOI] 10.1016/j.talanta.2024.125923.
[PMID] 38569366.
2024
Multiple-Dose Pharmacokinetics and Safety of Mitragynine, the Major Alkaloid of Kratom, in Rats.
ACS pharmacology & translational science.
7(8):2452-2464
[DOI] 10.1021/acsptsci.4c00277.
[PMID] 39144552.
2024
Pharmacokinetic Interaction of Kratom and Cannabidiol in Male Rats.
Pharmaceutics.
16(3)
[DOI] 10.3390/pharmaceutics16030318.
[PMID] 38543213.
2024
Responses to a “Typical” Morning Dose of Kratom in People Who Use Kratom Regularly: A Direct-Observation Study.
Journal of addiction medicine.
18(2):144-152
[DOI] 10.1097/ADM.0000000000001259.
[PMID] 38174871.
2023
An in vitro evaluation of kratom (Mitragyna speciosa) on the catalytic activity of carboxylesterase 1 (CES1).
Chemico-biological interactions.
384
[DOI] 10.1016/j.cbi.2023.110715.
[PMID] 37716419.
2023
Cannabidiol and mitragynine exhibit differential interactive effects in the attenuation of paclitaxel-induced mechanical allodynia, acute antinociception, and schedule-controlled responding in mice
Pharmacological Reports.
75(4):937-950
[DOI] 10.1007/s43440-023-00498-w.
[PMID] 37243887.
2023
Characterization of a Mouse Model of Neuropathic Pain Induced by Calcaneus Implantation of NCTC 2472 Mouse Sarcoma Cells
ASPET 2023 Annual Meeting Abstract – Cancer Pharmacology.
[DOI] 10.1124/jpet.122.243040.
2023
Metabolite and Molecular Characterization of Mitragyna speciosa Identifies Developmental and Genotypic Effects on Monoterpene Indole and Oxindole Alkaloid Composition.
Journal of natural products.
86(4):1042-1052
[DOI] 10.1021/acs.jnatprod.3c00092.
[PMID] 36913648.
2023
Mitragynine Pretreatment Prevents Morphine-Induced Respiratory Depression
ASPET 2023 Annual Meeting Abstract – Toxicology.
[DOI] 10.1124/jpet.122.261220.
2023
Receptor Selectivity and Therapeutic Potential of Kratom in Substance Use Disorders
Current Addiction Reports.
[DOI] 10.1007/s40429-023-00472-9.
2022
Effects of Mitragynine and its Active Metabolites on the Reinforcing Effects of Remifentanil and Cocaine in Rats Self‐Administering Remifentanil
The FASEB Journal.
36(S1)
[DOI] 10.1096/fasebj.2022.36.s1.r5776.
2020
Antileishmanial assessment of isoxazole derivatives against L. donovani
RSC Medicinal Chemistry.
11(9):1053-1062
[DOI] 10.1039/d0md00083c.
[PMID] 33479698.
2019
Applications of Sodium Nitrite in Organic Synthesis
European Journal of Organic Chemistry.
2019(38):6424-6451
[DOI] 10.1002/ejoc.201900951.
2019
NaNO2/I2 as an alternative reagent for the synthesis of 1,2,3-benzotriazin-4(3H)-ones from 2-aminobenzamides
Tetrahedron Letters.
60(3):248-251
[DOI] 10.1016/j.tetlet.2018.12.025.
2018
Direct Transformation of Arylamines to Aryl Halides via Sodium Nitrite and N
-Halosuccinimide
Chemistry – A European Journal.
24(55):14622-14626
[DOI] 10.1002/chem.201803347.
[PMID] 30040166.
2018
TBHP as Methyl Source under Metal-Free Aerobic Conditions To Synthesize Quinazolin-4(3H
)-ones and Quinazolines by Oxidative Amination of C(sp3
)-H Bond
European Journal of Organic Chemistry.
2018(22):2784-2794
[DOI] 10.1002/ejoc.201800495.
2017
Efficient Transformation of Alkyl 3-nitro-5-(aryl/alkyl)isoxazole-4-carboxylates into 3-amino- and 3-hydrazinyl-5-aryl/alkyl-isoxazole-4-carboxylates in Aqueous Solution
Advanced Synthesis & Catalysis.
359(22):4050-4056
[DOI] 10.1002/adsc.201700881.
2016
Corrigendum: Synthesis of 3,4,5-Trisubstituted Isoxazoles from Morita-Baylis-Hillman Acetates by an NaNO2/I2-Mediated Domino Reaction.
Angewandte Chemie (International ed. in English).
55(4)
[DOI] 10.1002/anie.201511039.
[PMID] 26779865.
2016
Metal-Free Oxidative Nitration of α-Carbon of Carbonyls Leads to One-Pot Synthesis of Thiohydroximic Acids from Acetophenones
Organic Letters.
18(17):4190-4193
[DOI] 10.1021/acs.orglett.6b01807.
[PMID] 27541178.
2016
NaNO2/I2-Mediated Regioselective Synthesis of Nitrosoimidazoheterocycles from Acetophenones by a Domino Process
European Journal of Organic Chemistry.
2016(22):3836-3844
[DOI] 10.1002/ejoc.201600553.
2015
Synthesis of 3,4,5-Trisubstituted Isoxazoles from Morita-Baylis-Hillman Acetates by an NaNO2 /I2 -Mediated Domino Reaction.
Angewandte Chemie (International ed. in English).
54(37):10926-30
[DOI] 10.1002/anie.201504529.
[PMID] 26215456.
2015
Synthesis of 3,4,5-Trisubstituted Isoxazoles from Morita-Baylis-Hillman Acetates by an NaNO2/I2-Mediated Domino Reaction
Angewandte Chemie.
127(37):11076-11080
[DOI] 10.1002/ange.201504529.
2014
Room-Temperature Chemoselective Reduction of Nitro Groups Using Non-noble Metal Nanocatalysts in Water
Inorganic Chemistry.
53(6):2904-2909
[DOI] 10.1021/ic402674z.
Education
PhD
2020
·
CSIR-Central Drug Research Institute, India
Master of Science in Chemistry
2011
·
University of Kalyani, India
Bachelor of Science in Chemistry
2009
·
University of Kalyani, India
Contact Details
Phones:
- Business:
- (352) 284-9649
Emails:
- Business:
- smukhopadhyay@ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100485
GAINESVILLE FL 32610