Mohamed O A Radwan

Mohamed O A Radwan, Ph.D.

Research Assistant Professor

Department: Pharmacodynamics
Business Phone: (352) 273-7700
Business Email: radwanm@ufl.edu

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0002-9220-2659

Publications

2024
Beyond Psychotropic: Potential Repurposing of Fluoxetine toward Cancer Therapy.
International journal of molecular sciences. 25(12) [DOI] 10.3390/ijms25126314. [PMID] 38928021.
2024
HIV-1 Gag MA domain binds to cardiolipin in a binding mode distinct from virus assemble mediator PI(4,5)P2.
Chemical biology & drug design. 103(1) [DOI] 10.1111/cbdd.14401. [PMID] 37985015.
2024
Ligand-based design and synthesis of new trityl histamine and trityl cysteamine derivatives as SIRT2 inhibitors for cancer therapy.
European journal of medicinal chemistry. 269 [DOI] 10.1016/j.ejmech.2024.116302. [PMID] 38484678.
2023
Gypsogenin Battling for a Front Position in the Pentacyclic Triterpenes Game of Thrones on Anti-Cancer Therapy: A Critical Review-Dedicated to the Memory of Professor Hanaa M. Rady.
Molecules (Basel, Switzerland). 28(15) [DOI] 10.3390/molecules28155677. [PMID] 37570648.
2023
Harnessing Oleanolic Acid and Its Derivatives as Modulators of Metabolic Nuclear Receptors.
Biomolecules. 13(10) [DOI] 10.3390/biom13101465. [PMID] 37892147.
2023
In vitro acetylcholinesterase, tyrosinase inhibitory potentials of secondary metabolites from Euphorbia schimperiana and Euphorbia balsamifera.
Zeitschrift fur Naturforschung. C, Journal of biosciences. 78(5-6):209-216 [DOI] 10.1515/znc-2021-0178. [PMID] 36321624.
2023
New insight into the bioactivity of substituted benzimidazole derivatives: Repurposing from anti-HIV activity to cell migration inhibition targeting hnRNP M.
Bioorganic & medicinal chemistry. 86 [DOI] 10.1016/j.bmc.2023.117294. [PMID] 37141680.
2023
Overview of Ursolic Acid Potential for the Treatment of Metabolic Disorders, Autoimmune Diseases, and Cancers via Nuclear Receptor Pathways.
Biomedicines. 11(10) [DOI] 10.3390/biomedicines11102845. [PMID] 37893218.
2023
Structural Characterization of TRAF6 N-Terminal for Therapeutic Uses and Computational Studies on New Derivatives.
Pharmaceuticals (Basel, Switzerland). 16(11) [DOI] 10.3390/ph16111608. [PMID] 38004473.
2022
A New 1,2-Naphthoquinone Derivative with Anti-lung Cancer Activity.
Chemical & pharmaceutical bulletin. 70(7):477-482 [DOI] 10.1248/cpb.c21-01087. [PMID] 35786566.
2022
Design, semi-synthesis and examination of new gypsogenin derivatives against leukemia via Abl tyrosine kinase inhibition and apoptosis induction.
International journal of biological macromolecules. 222(Pt A):1487-1499 [DOI] 10.1016/j.ijbiomac.2022.09.257. [PMID] 36195231.
2022
Discovery of Azaindolin-2-One as a Dual Inhibitor of GSK3╬▓ and Tau Aggregation with Potential Neuroprotective Activity.
Pharmaceuticals (Basel, Switzerland). 15(4) [DOI] 10.3390/ph15040426. [PMID] 35455423.
2022
In Vitro and In Silico Study to Assess Toxic Mechanisms of Hybrid Molecules of Quinone-Benzocaine as Plastoquinone Analogues in Breast Cancer Cells.
ACS omega. 7(34):30250-30264 [DOI] 10.1021/acsomega.2c03428. [PMID] 36061710.
2022
Natural-product-inspired design and synthesis of thiolated coenzyme Q analogs as promising agents against Gram-positive bacterial strains: insights into structure-activity relationship, activity profile, mode of action, and molecular docking.
RSC advances. 12(32):20507-20518 [DOI] 10.1039/d2ra02136f. [PMID] 35919160.
2022
New Insights into the Structural Requirements of Isatin-Derived Pro-Apoptotic Agents against Acute Myeloid Leukemia.
Pharmaceuticals (Basel, Switzerland). 15(12) [DOI] 10.3390/ph15121579. [PMID] 36559030.
2022
Promising Antibacterial and Antifungal Agents Based on Thiolated Vitamin K3 Analogs: Synthesis, Bioevaluation, Molecular Docking.
Pharmaceuticals (Basel, Switzerland). 15(5) [DOI] 10.3390/ph15050586. [PMID] 35631412.
2021
A New Inhibitor of ADAM17 Composed of a Zinc-Binding Dithiol Moiety and a Specificity Pocket-Binding Appendage.
Chemical & pharmaceutical bulletin. 69(11):1123-1130 [DOI] 10.1248/cpb.c21-00701. [PMID] 34719595.
2021
A New Series of Antileukemic Agents: Design, Synthesis, In Vitro and In Silico Evaluation of Thiazole-Based ABL1 Kinase Inhibitors.
Anti-cancer agents in medicinal chemistry. 21(9):1099-1109 [DOI] 10.2174/1871520620666200824100408. [PMID] 32838725.
2021
EGFR-Targeted Pentacyclic Triterpene Analogues for Glioma Therapy.
International journal of molecular sciences. 22(20) [DOI] 10.3390/ijms222010945. [PMID] 34681605.
2021
First In Class (S,E)-11-[2-(Arylmethylene)Hydrazono]-PBD Analogs As Selective CB2 Modulators Targeting Neurodegenerative Disorders.
Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents. 30(1):98-108 [DOI] 10.1007/s00044-020-02640-2. [PMID] 33776384.
2021
Genus Sophora: a comprehensive review on secondary chemical metabolites and their biological aspects from past achievements to future perspectives.
Archives of pharmacal research. 44(11):903-986 [DOI] 10.1007/s12272-021-01354-2. [PMID] 34907492.
2021
Selective SIRT2 inhibitors as promising anticancer therapeutics: An update from 2016 to 2020.
European journal of medicinal chemistry. 224 [DOI] 10.1016/j.ejmech.2021.113709. [PMID] 34303869.
2020
A novel series of chlorinated plastoquinone analogs: Design, synthesis, and evaluation of anticancer activity.
Chemical biology & drug design. 95(3):343-354 [DOI] 10.1111/cbdd.13651. [PMID] 31785034.
2020
Anticancer activity of Turkish marine extracts: a purple sponge extract induces apoptosis with multitarget kinase inhibition activity.
Investigational new drugs. 38(5):1326-1333 [DOI] 10.1007/s10637-020-00911-8. [PMID] 32062733.
2020
HSP70 induction by bleomycin metal core analogs.
Bioorganic & medicinal chemistry letters. 30(7) [DOI] 10.1016/j.bmcl.2020.127002. [PMID] 32044184.
2020
In Vitro and In Silico Evaluation of Anticancer Activity of New Indole-Based 1,3,4-Oxadiazoles as EGFR and COX-2 Inhibitors.
Molecules (Basel, Switzerland). 25(21) [DOI] 10.3390/molecules25215190. [PMID] 33171861.
2020
Interruption of Vif/Elongin C interaction: In silico and experimental elucidation of the underlying molecular mechanism of benzimidazole-based APOBEC3G stabilizers.
Bioorganic & medicinal chemistry. 28(8) [DOI] 10.1016/j.bmc.2020.115409. [PMID] 32169404.
2020
Pentabromobenzyl-RP versus triazole-HILIC columns for separation of the polar basic analytes famotidine and famotidone: LC method development combined with in silico tools to follow the potential consequences of famotidine gastric instability.
Journal of pharmaceutical and biomedical analysis. 186 [DOI] 10.1016/j.jpba.2020.113305. [PMID] 32353682.
2020
Structure activity study of S-trityl-cysteamine dimethylaminopyridine derivatives as SIRT2 inhibitors: Improvement of SIRT2 binding and inhibition.
Bioorganic & medicinal chemistry letters. 30(19) [DOI] 10.1016/j.bmcl.2020.127458. [PMID] 32755678.
2019
Antileukemic Activity of Twig Components of Caucasian Beech in Turkey.
Molecules (Basel, Switzerland). 24(21) [DOI] 10.3390/molecules24213850. [PMID] 31731511.
2019
Antiproliferative S-Trityl-l-Cysteine -Derived Compounds as SIRT2 Inhibitors: Repurposing and Solubility Enhancement.
Molecules (Basel, Switzerland). 24(18) [DOI] 10.3390/molecules24183295. [PMID] 31510043.
2019
Design, synthesis and biological evaluation of a new series of thiazolyl-pyrazolines as dual EGFR and HER2 inhibitors.
European journal of medicinal chemistry. 182 [DOI] 10.1016/j.ejmech.2019.111648. [PMID] 31493743.
2019
Design, synthesis, and biological activity of Plastoquinone analogs as a new class of anticancer agents.
Bioorganic chemistry. 92 [DOI] 10.1016/j.bioorg.2019.103255. [PMID] 31542717.
2019
Discovery and structure-activity relationship of plastoquinone analogs as anticancer agents against chronic myelogenous leukemia cells.
Archiv der Pharmazie. 352(12) [DOI] 10.1002/ardp.201900170. [PMID] 31602720.
2019
Estimation of nizatidine gastric nitrosatability and product toxicity via an integrated approach combining HILIC, in silico toxicology, and molecular docking.
Journal of food and drug analysis. 27(4):915-925 [DOI] 10.1016/j.jfda.2019.08.001. [PMID] 31590763.
2019
Minimum structural requirements for inhibitors of the zinc finger protein TRAF6.
Bioorganic & medicinal chemistry letters. 29(16):2162-2167 [DOI] 10.1016/j.bmcl.2019.06.050. [PMID] 31272791.
2019
New SIRT2 inhibitors: Histidine-based bleomycin spin-off.
Bioorganic & medicinal chemistry. 27(9):1767-1775 [DOI] 10.1016/j.bmc.2019.03.003. [PMID] 30885568.
2019
Novel p97/VCP inhibitor induces endoplasmic reticulum stress and apoptosis in both bortezomib-sensitive and -resistant multiple myeloma cells.
Cancer science. 110(10):3275-3287 [DOI] 10.1111/cas.14154. [PMID] 31368616.
2018
Bioactive products from singlet oxygen photooxygenation of cannabinoids.
European journal of medicinal chemistry. 143:983-996 [DOI] 10.1016/j.ejmech.2017.11.043. [PMID] 29232588.
2018
The First Pentacyclic Triterpenoid Gypsogenin Derivative Exhibiting Anti-ABL1 Kinase and Anti-chronic Myelogenous Leukemia Activities.
Biological & pharmaceutical bulletin. 41(4):570-574 [DOI] 10.1248/bpb.b17-00902. [PMID] 29386476.
2017
A Dithiol Compound Binds to the Zinc Finger Protein TRAF6 and Suppresses Its Ubiquitination.
ChemMedChem. 12(23):1935-1941 [DOI] 10.1002/cmdc.201700399. [PMID] 28884970.
2017
A novel inhibitor of farnesyltransferase with a zinc site recognition moiety and a farnesyl group.
Bioorganic & medicinal chemistry letters. 27(16):3862-3866 [DOI] 10.1016/j.bmcl.2017.06.047. [PMID] 28666734.
2017
Design, Synthesis, and Biological Evaluation of Novel 1,3,4-Thiadiazole Derivatives as Potential Antitumor Agents against Chronic Myelogenous Leukemia: Striking Effect of Nitrothiazole Moiety.
Molecules (Basel, Switzerland). 23(1) [DOI] 10.3390/molecules23010059. [PMID] 29280989.
2017
Marine Inspired 2-(5-Halo-1H-indol-3-yl)-N,N-dimethylethanamines as Modulators of Serotonin Receptors: An Example Illustrating the Power of Bromine as Part of the Uniquely Marine Chemical Space.
Marine drugs. 15(8) [DOI] 10.3390/md15080248. [PMID] 28792478.
2016
Zinc-mediated binding of a low-molecular-weight stabilizer of the host anti-viral factor apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G.
Bioorganic & medicinal chemistry. 24(18):4398-4405 [DOI] 10.1016/j.bmc.2016.07.030. [PMID] 27475536.
2015
Clinical and prognostic features of erionite-induced malignant mesothelioma.
Yonsei medical journal. 56(2):311-23 [DOI] 10.3349/ymj.2015.56.2.311. [PMID] 25683976.
2010
Antidepressant-like effect of delta9-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa L.
Pharmacology, biochemistry, and behavior. 95(4):434-42 [DOI] 10.1016/j.pbb.2010.03.004. [PMID] 20332000.
2010
Protective effect of trapidil and l-arginine against renal and hepatic toxicity induced by cyclosporine in rats.
Renal failure. 32(8):959-68 [DOI] 10.3109/0886022X.2010.501933. [PMID] 20722564.

Contact Details

Phones:
Business:
(352) 273-7700
Emails:
Business:
radwanm@ufl.edu
Addresses:
Business Street:
1345 Center Drive
GAINESVILLE FL 32610