Yufeng Xiao, Ph.D., MMed
Assistant Scientist
Research Profile
Areas of Interest
- Medicinal chemistry
- Proximity inducing modalities
- Small molecule drug discovery
- Targeted protein degradation
Publications
Academic Articles
2024
Discovery of a Highly Potent and Selective HDAC8 Degrader: Advancing the Functional Understanding and Therapeutic Potential of HDAC8.
Journal of medicinal chemistry.
67(15):12784-12806
[DOI] 10.1021/acs.jmedchem.4c00761.
[PMID] 38949959.
2024
Discovery of GPR84 Fluorogenic Probes Based on a Novel Antagonist for GPR84 Bioimaging.
Journal of medicinal chemistry.
[DOI] 10.1021/acs.jmedchem.4c00359.
[PMID] 38946306.
2024
GNAS knockout potentiates HDAC3 inhibition through viral mimicry-related interferon responses in lymphoma.
Leukemia.
38(10):2210-2224
[DOI] 10.1038/s41375-024-02325-4.
[PMID] 39117798.
2024
PROTAC-mediated NR4A1 degradation as a novel strategy for cancer immunotherapy.
The Journal of experimental medicine.
221(3)
[DOI] 10.1084/jem.20231519.
[PMID] 38334978.
2024
Targeted Protein Degradation: Current and Emerging Approaches for E3 Ligase Deconvolution.
Journal of medicinal chemistry.
67(14):11580-11596
[DOI] 10.1021/acs.jmedchem.4c00723.
[PMID] 38981094.
2023
HDAC3 and HDAC8 PROTAC dual degrader reveals roles of histone acetylation in gene regulation.
Cell chemical biology.
30(11):1421-1435.e12
[DOI] 10.1016/j.chembiol.2023.07.010.
[PMID] 37572669.
2023
Piperlongumine conjugates induce targeted protein degradation.
Cell chemical biology.
30(2):203-213.e17
[DOI] 10.1016/j.chembiol.2023.01.004.
[PMID] 36750097.
2023
Targeting intracellular proteins with cell type-specific functions for cancer immunotherapy
Life Medicine.
2(3)
[DOI] 10.1093/lifemedi/lnad019.
[PMID] 39872303.
2023
Unleashing the Power of NR4A1 Degradation as a Novel Strategy for Cancer Immunotherapy.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2023.08.09.552650.
[PMID] 37609171.
2022
Phosphodiesters as GPR84 Antagonists for the Treatment of Ulcerative Colitis
Journal of Medicinal Chemistry.
65(5):3991-4006
[DOI] 10.1021/acs.jmedchem.1c01813.
2020
Discovery of histone deacetylase 3 (HDAC3)-specific PROTACs.
Chemical communications (Cambridge, England).
56(68):9866-9869
[DOI] 10.1039/d0cc03243c.
[PMID] 32840532.
2020
Recent advances in small molecular modulators targeting histone deacetylase 6
Future Drug Discovery.
2(4)
[DOI] 10.4155/fdd-2020-0023.
2019
Sulfuretin protects hepatic cells through regulation of ROS levels and autophagic flux.
Acta pharmacologica Sinica.
40(7):908-918
[DOI] 10.1038/s41401-018-0193-5.
[PMID] 30560904.
Grants
Jun 2023
ACTIVE
UF Health Cancer Center Support Grant
Role: Project Manager
Funding: NATL INST OF HLTH NCI
Contact Details
Phones:
- Business:
- (352) 273-7714
Emails:
- Business:
- yufengxiao@ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100485
GAINESVILLE FL 32610 - Business Street:
-
1345 CENTER DR
GAINESVILLE FL 32610