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UF Health University of Florida
Department of Medicinal Chemistry College of Pharmacy
Yufeng Xiao

Yufeng Xiao, Ph.D., MMed

Assistant Scientist

Department: Medicinal Chemistry
Business Phone: (352) 273-7714
Business Email: yufengxiao@ufl.edu
CV: View Curriculum Vitae

Research Profile

Areas of Interest
  • Medicinal chemistry
  • Proximity inducing modalities
  • Small molecule drug discovery
  • Targeted protein degradation

Publications

Academic Articles
2024
Discovery of a Highly Potent and Selective HDAC8 Degrader: Advancing the Functional Understanding and Therapeutic Potential of HDAC8.
Journal of medicinal chemistry. 67(15):12784-12806 [DOI] 10.1021/acs.jmedchem.4c00761. [PMID] 38949959.
PubMed · Publisher’s Site
2024
Discovery of GPR84 Fluorogenic Probes Based on a Novel Antagonist for GPR84 Bioimaging.
Journal of medicinal chemistry. [DOI] 10.1021/acs.jmedchem.4c00359. [PMID] 38946306.
PubMed · Publisher’s Site
2024
GNAS knockout potentiates HDAC3 inhibition through viral mimicry-related interferon responses in lymphoma.
Leukemia. 38(10):2210-2224 [DOI] 10.1038/s41375-024-02325-4. [PMID] 39117798.
PubMed · Publisher’s Site
2024
PROTAC-mediated NR4A1 degradation as a novel strategy for cancer immunotherapy.
The Journal of experimental medicine. 221(3) [DOI] 10.1084/jem.20231519. [PMID] 38334978.
1 citation · PubMed · Publisher’s Site
2024
Targeted Protein Degradation: Current and Emerging Approaches for E3 Ligase Deconvolution.
Journal of medicinal chemistry. 67(14):11580-11596 [DOI] 10.1021/acs.jmedchem.4c00723. [PMID] 38981094.
2 citations · PubMed · Publisher’s Site
2023
HDAC3 and HDAC8 PROTAC dual degrader reveals roles of histone acetylation in gene regulation.
Cell chemical biology. 30(11):1421-1435.e12 [DOI] 10.1016/j.chembiol.2023.07.010. [PMID] 37572669.
4 citations · PubMed · Publisher’s Site
2023
Piperlongumine conjugates induce targeted protein degradation.
Cell chemical biology. 30(2):203-213.e17 [DOI] 10.1016/j.chembiol.2023.01.004. [PMID] 36750097.
13 citations · PubMed · Publisher’s Site
2023
Targeting intracellular proteins with cell type-specific functions for cancer immunotherapy
Life Medicine. 2(3) [DOI] 10.1093/lifemedi/lnad019.
Publisher’s Site
2023
Unleashing the Power of NR4A1 Degradation as a Novel Strategy for Cancer Immunotherapy.
bioRxiv : the preprint server for biology. [DOI] 10.1101/2023.08.09.552650. [PMID] 37609171.
PubMed · Publisher’s Site
2022
Phosphodiesters as GPR84 Antagonists for the Treatment of Ulcerative Colitis
Journal of Medicinal Chemistry. 65(5):3991-4006 [DOI] 10.1021/acs.jmedchem.1c01813.
Publisher’s Site
2020
Discovery of histone deacetylase 3 (HDAC3)-specific PROTACs.
Chemical communications (Cambridge, England). 56(68):9866-9869 [DOI] 10.1039/d0cc03243c. [PMID] 32840532.
59 citations · PubMed · Publisher’s Site
2020
Recent advances in small molecular modulators targeting histone deacetylase 6
Future Drug Discovery. 2(4) [DOI] 10.4155/fdd-2020-0023.
Publisher’s Site
2019
Sulfuretin protects hepatic cells through regulation of ROS levels and autophagic flux.
Acta pharmacologica Sinica. 40(7):908-918 [DOI] 10.1038/s41401-018-0193-5. [PMID] 30560904.
12 citations · PubMed · Publisher’s Site

Contact Details

Phones:
Business:
(352) 273-7714
Emails:
Business:
yufengxiao@ufl.edu
Addresses:
Business Mailing:
PO Box 100485
 GAINESVILLE FL 32610
Business Street:
1345 CENTER DR
 GAINESVILLE FL 32610